SEQUENTIAL PATHOLOGICAL CHANGES IN TURKEYS EXPERIMENTALLY INFECTED WITH CHICKEN POX VIRUS
Muhammd Mubarak and Muhammad Mahmoud
A total of 25, 4-weeks old, turkey poults were used in the present study. Birds were inoculated by chicken pox virus at the dose of 3 x l07.6/ml. Skin biopsy samples were taken sequentially from the same inoculated bird at 12 and 24 hours and at 2nd, 3rd, 4'h, 5th, 7th, l0th, 14th and 21 days post inoculation (PI). Tissue samples from upper respiratory and digestive tracts were also collected. Pox cytoplasmic inclusions (Bollinger bodies) were detected between 4 and 7 days PI in epidermal the cell as well as in the follicular and sinus epithelium. Proliferative and necrobiotic epithelial changes were observed. Thereafter, pox inclusions disappeared with the appearance of vesicular, pustular and ulcerative lesions. This was accompanied by the gradual development of granulation tissue and finally scar tissue formed. Ultrastructure of the inclusion bodies and fine changes of the affected epidermal cell were illustrated.. It was concluded that the inoculated chicken pox virus is highly pathogenic for turkeys. Taking sequential biopsy samples from the same inoculated bird was found to yield more accurate follow up of the pox skin lesions.
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