INTRATHORACIC AND EXTRATHORACIC METASTASES IN PIRLAK EWES WITH OVINE PULMONARY ADENOCARCINOMA (JAAGSIEKTE)
2024
Belma Dayı | Marcelo De Las Heras | Alper Sevimli
Ovine pulmonary adenocarcinoma (OPA) is a contagious neoplastic disease caused by jaagsiekte sheep retrovirus (JSRV) and is characterized by chronic respiratory clinical signs. In this study we describe intrathoracic and extrathoracic metastases in Pırlak ewes naturally infected with JSRV. Two Pırlak sheep flocks brought from two different provinces had progressive respiratory distress, nasal discharge, cough, and emaciation, and nine ewes from these two flocks were necropsied at the request of the owners. Gross findings revealed purple colored and consolidated cranioventral lung lobes with scattered white nodules of various sizes. One ewe had metastasis in the mediastinal lymph node, and another had metastasis in the left kidney. Histopathological examinations of the tumors in the lungs and metastases showed papillary and acinary growth patterns. Immunohistochemically, strong JSRV-Env expression was observed in neoplastic cells.
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