Reference intervals using the dry-system coagulation analyzer COAG2V for blood coagulation tests in dogs
2019
Irie, Y. (Kanbayashi Animal Hospital, Joyo-shi (Japan)) | Yoshida, H. | Kai, K. | Makino, Y. | Shibata, S. | Kitoh, K.
This study was performed to determine reference intervals using a dry-system coagulation analyzer (COAG2V) for blood coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (APTT), plasma fibrinogen concentration (Fib), thrombotest (TB) and hepaplastin test (HPT) in dogs. We assessed the coagulation variables in citrated plasma samples from 123 healthy dogs with a median age of 5 years and evenly distributed sex. We first checked the data from each of the five variables for normal distribution, and then we identified and eliminated outliers using Tukey's method. We defined the reference intervals as the mean ± 1.96 standard deviations of the data. The reference intervals were as follows: PT 7.1 - 8.4 sec, TB 11.7 - 14.6 sec, HPT 9.8 - 16.2 sec, and APTT 13.7 - 25.6 sec. For Fib where the data were not normally distributed, the values were log-transformed (to base e) and were then assessed in the same way as for the raw data. As a result, the reference interval for Fib was 113 - 385 mg/dl. This study provided reference intervals for coagulation variables using a point-of care coagulation analyzer COAG2V in dogs. The reference intervals will be useful in differentiating healthy dogs from dogs with coagulopathies.
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