A clinical case of autosomal recessive cholesterol deficiency in a 29-month-old Holstein dairy cow homozygous for the causative gene
2019
Moriyama, S. (Obihiro University of Agriculture and Veterinary Medicine (Japan). Department of Clinical Veterinary Medicine) | Fujita, H. | Kiuchi, K. | Watanabe, K. | Horiuchi, N. | Kobayashi, Y. | Inokuma, H.
A 29-month-old Holstein dairy cow presented with astasia and shock-like symptoms after calving. Autosomal recessive cholesterol deficiency (CD) was suspected from markedly low serum total cholesterol (6 mg/ dl). A PCR test confirmed homozygosity for the gene responsible for CD. Marked emaciation, anemia and muddy stool were noted on physical examination, and acanthocytes were found in the blood smear. Decreased body fat was notable during necropsy. All of these findings were consistent with those of homozygous calves previously reported. Although most homozygous individuals with CD are reported to die by the age of 6 months, the present report confirmed that some cows with CD can survive to the first calving.
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