Tartaric acid synthetic derivatives effect on phytopathogenic bacteria

The scientific goals of current research were devoted to targeted derivatization of natural tartaric acid (TA) for the enhancement of antimicrobial properties of it such as like the effects of them on multi-drug resistant phytopathogenic bacteria, depends to their structure features and the genetic parameters of studied microorganisms. The main utilitarian goal is to develop new class of antimicrobial biodegradable compounds with possible prospective application as moresafe alternative to traditional antibiotics applicable for: agriculture, horticulture, food industry as well as in medicine. These compounds were developed in basic research laboratory: ‘Agrarian Pesticide Creation and The Quality Control’ at National Polytechnic University of Armenia (NPUA). TA and tartrates are safe antimicrobial food additives. According to the results of in vitro studies, the synthesized cyclohexyl-, benzyl- and phenyl- derivatives of it in the form of amine complex salts (correspondently CAS, BAS and PhAS) and cyclic imides (correspondently CI, BI and PhI) are effective against the model multidrug resistant strains of Gram-negative microorganisms. Bactericidal effects of TA derivatives were demonstrated on 19 model native soil strains of phytopathogenic Xanthomonas beticola (6 strains), X. vesicatoria and Pseudomonas syringae (13 strains) representatives, which are differing in antibiotic resistance. Regarding the transformation results, the absence of transfer of resistance to TA imides and amine complex salts by plasmids, makes them promising objects for further research. Primary studies have not shown any antibacterial effect on various nonpathogenic soil bacteria (Pseudomonas chlororaphis, P. taetrolens, etc.). The described compounds are recommended for further more detailed toxicological studies.