Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several generations of scrapie-infected sheep
Moreno-Romieux, Carole | Moazami-Goudarzi, Katayoun | Briand, Stéphanie | Robert-Granié, Christèle | Weisbecker, Jean Louis | Laurent, Pascal | Cribiu, Edmond | Haley, Christopher S. | Andreoletti, Olivier | Bishop, Stephen C. | Pong-Wong, Ricardo | Station d'Amélioration Génétique des Animaux (SAGA) ; Institut National de la Recherche Agronomique (INRA) | Génétique Animale et Biologie Intégrative (GABI) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Domaine expérimental de Langlade (LANGLADE) ; Institut National de la Recherche Agronomique (INRA) | The Roslin Institute ; Biotechnology and Biological Sciences Research Council (BBSRC) | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)
Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ/VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on chromosome 18, and to demonstrate the QTL effects in several PrP genotypes.
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