Analysis of macrolide antibiotics in water by magnetic solid-phase extraction and liquid chromatography–tandem mass spectrometry
2017
Pérez Martín, Rosa Ana | Albero Romano, María Beatriz | Férriz, Macarena | Tadeo Lluch, José Luis | Férriz, Macarena [0000-0003-2512-5187]
Macrolides are one of the most commonly used families of antibiotics employed in human and veterinary treatment. These compounds are considered emerging contaminants with potential ecological and human health risks that could be present in surface water. This paper describes the development and application of a simple and efficient extraction procedure for the determination of tilmicosin; erythromycin, tylosin and erythromycin-H2O from water samples. Sample extraction was carried out using magnetic solid-phase extraction using oleate functionalized magnetic nanoparticles followed by LC–MS/MS analysis. The effects of several parameters on the extraction efficiency of MLs from water were evaluated. The recovery results obtained were >84% for most of the compounds, except for erytromycin. The LOD and LOQ values ranged from 11.5 to 26 ng L−1 and from 34 to 77 ng L−1, respectively. The selected method was applied to monitor these contaminants in water samples from different sources. Tilmicosin and tylosin were not detected in any of the samples, but erythromycin and erythromycin-H2O were found in 50% of the surface water samples at levels from <LOQ to 264 ng L−1 and 149 ng L−1, respectively. © 2017 Elsevier B.V.
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