Endocrinology of reproductive function and pregnancy at high altitudes
Parraguez, V. H. | González De Bulnes, Antonio | Fondo Nacional de Desarrollo Científico y Tecnológico (Chile) | Comisión Nacional de Investigación Científica y Tecnológica (Chile) | Universidad de Chile | Agencia Española de Cooperación Internacional para el Desarrollo | Parraguez, V. H. [0000-0002-3621-2705] | González De Bulnes, Antonio [0000-0002-0917-4475]
Reproductive function and therefore fertility, both in women and men, are affected by the high altitude environment. Hypobaric hypoxia affects functionality of the hypothalamus–hypophysis–gonads axis, sperm quality, cyclic ovulatory activity, and quality of preovulatory follicles, oocytes, corpora lutea, and embryos. Hence, chances for obtaining pregnancy are diminished in humans and animals living at high altitudes. The occurrence of intrauterine growth restriction is around 3-fold higher than that at low altitude. Most of these deficiencies are related not only to hypoxia but also to increased oxidative stress. Hence, supplementation with antioxidant agents may constitute a useful strategy.
Показать больше [+] Меньше [-]This work was supported by Projects Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1020706, 1070405, 1100189, and 1130181 from Comisión Nacional de Investigación Científica y Tecnológica (CONICYT); Project DID- ENL 06/2 from Universidad de Chile; Projects Agencia Española de Cooperación Internacional para el Desarrollo (AECID) A/023494/09 and A/030536/10) from the Spain Government.
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