Polyamines as Quality Control Metabolites Operating at the Post-Transcriptional Level
Poidevin, Laetitia | Unal, Dilek | Belda-Palazón, Borja | Ferrando, Alejandro | Consejo Superior de Investigaciones Científicas (España) | Ministerio de Economía y Competitividad (España) | Generalitat Valenciana | EMBO
Plant polyamines (PAs) have been assigned a large number of physiological functions with unknown molecular mechanisms in many cases. Among the most abundant and studied polyamines, two of them, namely spermidine (Spd) and thermospermine (Tspm), share some molecular functions related to quality control pathways for tightly regulated mRNAs at the level of translation. In this review, we focus on the roles of Tspm and Spd to facilitate the translation of mRNAs containing upstream ORFs (uORFs), premature stop codons, and ribosome stalling sequences that may block translation, thus preventing their degradation by quality control mechanisms such as the nonsense-mediated decay pathway and possible interactions with other mRNA quality surveillance pathways.
Показать больше [+] Меньше [-]A.F. was funded by the Spanish Ministry of Science, Innovation and Universities, grant number BIO2015-70483-R, and B.B.-P. was funded by the Generalitat Valenciana grant, VALi+d GVA APOSTD/2017/039. D.U. was a recipient of an EMBO short-term fellowship, number STF-7308
Показать больше [+] Меньше [-]We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)
Показать больше [+] Меньше [-]Peer reviewed
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