Compatibility of the microbial product 035 (Bacillus subtilis) with decoquinate and narasin/nicarbazin
(FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed
Following a request from the European Commission, the European Food Safety Authority (EFSA) was asked to deliver a scientific opinion on the compatibility of the microbial product 035 (Bacillus subtilis) with decoquinate and narasin/nicarbazin. A 35-day compatibility trial with 450 one-day-old male chickens divided into one control and four test groups was performed. The birds received the recommended dose of 035 (8 x 108 CFU kg-1, confirmed by microbiological analysis) and each of the four experimental groups, one of the following coccidiostats: decoquinate, robenidine, diclazuril or narasin/nicarbazin, at the highest authorised dose levels. The birds were observed for mortality and morbidity, body weight gain and feed conversion. On day 14, one bird from every cage was randomly selected and analysed for the caecal content of bacilli. At the end of the trial the analyses were repeated using three birds per cage, the total number of analysed birds being 180. There were no statistically significant differences between the groups in the weight gain or feed to gain ratio. The presence of the coccidiostats decoquinate or narasin/nicarbazin did not significantly reduce Bacillus counts. Given the number of replicates, those results are considered reliable and allow the conclusion that 035 is compatible in vivo with decoquinate and narasin/nicarbazin when used at the authorised levels. The study also included matching data on the coccidiostats robenidine and diclazuril. The results confirm the compatibility of 035 with those two coccidostats.
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Библиографическая информация
Эту запись предоставил Friedrich-Loeffler-Institut