Transfer of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from contaminated feed into milk and meat of sheep: Pilot study
Kowalczyk, J. | Ehlers, S. | Fürst, P. | Schafft, H. | Lahrssen-Wiederholt, M.
A pilot study was performed with dairy sheep to generate the first data on the transfer of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from feed into food of animal origin. Corn silage was cultivated on cropland in Lower Saxony in Germany where, as a result of illegal waste disposal in 2006, farmland was contaminated with perfluorinated alkylacids (PFAAs). Two sheep were exposed by way of PFAA-contaminated corn silage to PFOS (1.16 and 1.45 ++g/kg body weight [bw]/d, respectively) and PFOA (0.43 and 0.53 ++g/kgbw/d) during a period of 21 days.During the PFAA-feeding period, PFOS levels in plasma increased continuously tomaximumconcentration of 103 and 240 ++g/L for sheep 1 and sheep 2, respectively. The PFOA plasma concentration remained low (sheep 1 = 3.3 -¦ 2.2 ++g/L; sheep 2 = 15.6 -¦ 8.3 ++g/L). Data indicate that urinary excretion is the primary clearance route for PFOA (sheep 1 = 51 %; sheep 2 = 55 %), whereas PFOS excretion by way of urine could not be quantified. The highest PFOS excretion (4 to 5 %) was detected in faeces. PFOS was also excreted at higher levels than PFOA by way ofmilk. During a period of 21 days, a total PFOS transfer into milk Ôëñ2 % was calculated. Overall, total excretion of PFOS was significantly lower compared with that of PFOA (PFOS 6 %; PFOA 53 to 56 %). PFOS levels in sheep 1 and sheep 2 were highest in liver (885 and 1,172 ++g/kg weight wet [ww], respectively) and lowest in muscle tissue (24.4 and 35.1 ++g/kg ww, respectively). PFOA levels in muscle tissue were low for sheep 2 (0.23 ++g/kg ww) and not detectable after the PFAAfree feeding period in sheep 1. A slight background load of PFOS in liver (1.5 ++g/kgww) and kidney (0.3 ++g/kgww)was detected in sheep 3 (control).
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Издатель Springer
ISSN 1432-0703 | 0090-4341Эту запись предоставил German Federal Institute for Risk Assessment