Drug-mediated toxicity: Illuminating the 'bad' in the test tube by means of cellular assays?

Tralau,T.; Luch,A.

Drug-mediated toxicity: Illuminating the 'bad' in the test tube by means of cellular assays?

2012

Tralau,T. | Luch,A.

Health problems are rising worldwide, be it as a consequence of lifestyle and longevity in increasingly affluent societies or due to a sharp rise in bacterial antibiotic resistance. The pharmaceutical industry is caught between high rates of attrition and the rather slow pace of a historically large regulatory system for pharmacological safety. Meanwhile, the past decade has seen a tremendous evolution of the biological toolbox, most notably of cellular assays, stem-cell differentiation and organ-mimicking systems. These systems were readily adapted for lead-compound identification. However, their use as toxicological test systems is lagging behind, not least because of a lack of regulatory acceptance. This review tries to elucidate the scale of the problem and discusses the applicability of the assays currently available, with particular regard to the use of stem cells. -® 2012 Elsevier Ltd. All rights reserved

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Ключевые слова АГРОВОК

agents analyse analysis animal animal animals apoptosis assessment behavior berlin biology cancer carcinogenesis carcinogenicity cell culture cell death cells cells cytochrome p450 cytotoxicity death delayed hypersensitivity detection development doxorubicin electrophysiology enzyme enzymes evaluation gene genotoxicity germany growth health heart humans identification in vitro industry inhibition innovation kinetics lead liver mass spectrometry metabolism metabolites methodology methods mice model models models monitoring muscle neurotoxicity ochratoxin phage pharmacology power prediction probe products profiles protein proteomics rat research risk risk assessment saccharomyces cerevisiae safety screening skin species species differences spectrometry standard state strategies stress system systems technology testing tests toxicity toxicity tests toxicology trends verapamil

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Опубликовано в

Trends in pharmacological sciences | Trends Pharmacol Sci | TIPS

Том 33 Выпуск 7 Нумерация страниц 353 - 364

Издатель Cell Press

ISSN 0165-6147 | 1873-3735

Другие темы

Product; Capacity; Note; Difference; Fibrosis; Antibiotic agent; Safety assessment; Agent; Antihistaminic agent; Mass-spectrometry; Cell culture techniques; Toxicogenomics; Toxic hepatitis; Hypericum perforatum extract; Penicillin derivative; Drug safety; Hepatocytes; Drug metabolism; Workshop; Cultured; In vitro test; Matrix; Bfr; Adult; Pharmaceutical; Studies; Toxicity testing; Reference; Pharmaceutical preparations; Culture; In vitro system; Mouse; Heart arrhythmia; Liver toxicity; Quantitation; Reactive metabolite; Risk-assessment; Pluripotent stem cell; Target; Drug clearance; Line; Compounds; Paracetamol; Trial; Clinical-trials; Metabolite; Drug; Human skin; Sotalol; Mechanisms; Stem cells; Drug screening; Diclofenac; Acute; Preclinical; Drug evaluation; Non-animal; Clinical trial; Drug-metabolism; Cell line; Nephrotoxicity; Pharmaceuticals; Study; Tgn 1412; Immunotoxicity; Cyclosporin derivative; Response; Biomarker; Torsade des pointes; Biomedical research; Extracellular matrix; Priority journal; Stage; Differentiation; Dog; Sensitivity; Cardiovascular disease; Genotoxic; Bioassay; Nonhuman; Hepatotoxicity; Genomic; 1 [2 (6 methyl 2 pyridyl)ethyl] 4 (4 methylsulfonylaminobenzoyl)piperidine; Chemical; Vitro; Assay; Cisapride; Growth-factor; Compound; Bioreactor; Grepafloxacin; In-vitro; Review; Biological marker; Rofecoxib; Genome; Discovery; In-vivo; Drug excretion; Cell; Pathways; Biomarkers; Drug targeting; Blood brain barrier; Characterization; In vivo; Ecvam; Skin model; Terfenadine; Human; Challenge; Biological assay; Inhibitor; Clinical; Microarray; Hazard; Liver metabolism; Proteomic; Recommendations; Targets; Strategy; Mechanism; Atazanavir; Embryonic stem cells; Report; Chemical compound; Hepatocyte; Prevalidation; Adefovir; Drug development; Cell assay; Lung toxicity; Qt prolongation; Species difference; Developmental toxicity; Potential; Pathway; Muscle relaxant agent; Cell viability; Method; In vitro tests; Vivo; Pancreas cell; Roflumilast; Perspective; Cardiotoxicity; Embryonic stem cell; Cell-line; High throughput screening; Immediate type hypersensitivity; Minocycline; Nifedipine; Approach; Animal testing; Cyp2e1; German; Technologies; Drug approval; Induction; Profile; Growth factor; Human skin models; Of-the-art; Sunitinib; 37; Natural

Язык

Английский

Тип

Journal Article; Text

В АГРИСе с: 2025-02-03

Дата изменения: 2026-02-03

Формат: MODS

Поставщик данных

Эту запись предоставил German Federal Institute for Risk Assessment

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Ссылки

DOI https://www.openagrar.de/receive/bimport_mods_00001346

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Drug-mediated toxicity: Illuminating the 'bad' in the test tube by means of cellular assays?

2012

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Библиографическая информация