Preventive Effects of Zingiber officinal on Chromium Trioxide Toxicity in the Reproductive Tract of Male Rat
El Imen Zerarki, Nour | Berroukche, Abdelkrim
Exposure to chromium trioxide (CrO3) is known to induce oxidative stress and damage to various tissues, including reproductive organs. Zingiber officinale has been reported to possess potent antioxidant and anti-inflammatory properties. This study aimed to investigate the protective effects of rhizobium ginger extract (RGE) on the prostate and testicular tissues of rats exposed to CrO3. Male rats were divided into four groups: GR1 (control), GR2 (CrO3 at 10 mg/kg ), GR3 (RGE-treated at 600 mg /kg) and GR4 (RGE + CrO3). Biochemical analyses were conducted to measure serum concentrations of prostate specific antigen (PSA) and testosterone. Histological examinations of prostate and testicular tissues were also performed. The CrO3-exposed rats (GR2) exhibited significant increases in PSA and testosterone levels respectively 0.93 and 0.98 ng/mL. Whereas RGE-treated rats (GR4) showed decreased serum-PSA (< 0.068 ng/mL) and testosterone (0.41 ng/mL). Histological study revealed tissue damage and inflammatory cell infiltration in the prostate and testicular tissues of CrO3-exposed rats (GR2). In contrast, rats treated with RGE (GR4) showed an improved tissue architecture and reduced inflammation compared to the CrO3-exposed group. The findings suggest that RGE mitigates CrO3-induced oxidative stress and tissue damage in the prostate and testicular tissues. This study highlights Zingiber officinale being a natural therapeutic agent against reproductive toxicity induced by heavy metals.
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