Preparation and trials of complex solid dispersion based on Fenbendazole and Niclozamide against monieziosis and gastro-intestinal nematode infection of sheep
2025
I. A. Arkhipov | A. I. Varlamova | S. S. Khalikov | K. M. Sadov | M. S. Khalikov
The purpose of the research is to study the anthelmintic efficacy of complex solid dispersion of fenbendazole (FBZ) and niclozamide (NZM) against monieziosis and gastro-intestinal nematode infection of sheep.Materials and methods. A complex solid dispersion was obtained by mechanochemical processing of FBZ, NZM and polyvinylpyrrolidone (PVP) substances in a ratio of 2 : 20 : 78 in LE-101 roller mill at an energy intensity level of 1 g for 4 hours at drum rotation speed of 60–70 rpm. The activity of the complex solid dispersion was studied on 119 sheep naturally infected with Moniezia expansa and gastro-intestinal strongyles. The sheep were divided into 3 groups for each disease. The complex solid dispersion was administered to the sheep of the first experimental groups once orally at a dose of 20 mg/kg of NZM against monieziosis and at a dose of 2 mg/kg of FBZ against gastro-intestinal nematode infection. The sheep of the second experimental groups received a mechanical mixture of FBZ, NZM and PVP in the same ratio in similar doses. The sheep of the 3 groups served as a control and did not receive any preparations. The efficacy of the drugs was calculated on the results of coproovoscopic studies using the flotation method before and 15 days after deworming according to the "control test".Results and discussion. The results of trials of complex solid dispersion against sheep helminthosis indicated 97.0% efficacy of the drug at a dose of 20 mg/kg of active substance (NZM) against monieziosis and 92.1% efficacy against gastrointestinal nematode infection at a dose of 2 mg/kg of FBZ. The basic drug – a mechanical mixture of FBZ and NZM in the same doses revealed 25.2–26.4 % efficacy.
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