REPRODUCTIVE EFFICACY IN FEMALE RAT EXPOSED TO BISPHENOL A DURING GESTATION PERIOD

Abdulrazzak N. Khudir Abdul Ameer A. Ismael; Ayyed H. Hassan

REPRODUCTIVE EFFICACY IN FEMALE RAT EXPOSED TO BISPHENOL A DURING GESTATION PERIOD

2013

Abdulrazzak N. Khudir Abdul Ameer A. Ismael | Ayyed H. Hassan

The study was conduct to determine the effect of exposure to Bisphenol A (BPA) during gestation on serum reproductive hormones levels (Estradiol" E2", Luteinizing Hormone "LH" and follicle- stimulating Hormone" FSH"), age and weight at vaginal opening onset as well as reproductive efficacy in F1 female offspring. Thirty six pregnant female rats (F0) were gavage three doses of BPA suspended in corn oil (50 μg, 50 mg, 250 mg/kg/BW) or corn oil only as control group from gestational day (GD) 6 till gestation day (GD) 21. After delivery, twelve female pups of each group were hold for three months; However, Female rats' offspring, after weaning, were weighed and checked for vaginal opening (VO) every day until completion, then at postnatal day (PND) 90, blood samples were collected from six F1 female of each group to perform hormonal tests and other six females were mated with untreated male rat in a separate cage for 14 days in order to evaluate fertility efficacy. The results showed significant increased (P

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