ANEW METHOD FOR ESTIMATION MEBENDAZOLE IN ITS PHARMACEUTICAL PREPARATIONS AND IN CAMEL URINE

ANEW METHOD FOR ESTIMATION MEBENDAZOLE IN ITS PHARMACEUTICAL PREPARATIONS AND IN CAMEL URINE

2018

A simple, accurate and rapid spectrophotometric method has been developed for the estimation of mebendazole in pure, pharmaceutical formulations and camel urine. The method is based on the reaction of mebendazole with1-fluoro 2, 4-dinitrobenzene to produce orange-yellow colored complex having maximum absorption at 494 nm. Beeˈs law was obeyed over the concentration range of 20-280μg/ml, with molar absorptivity of 3.32x104 l/mol.cm. The present method is considered to be simple because it does not need heating, hydrolysis, and solvent extraction steps. The proposed method has been successfully applied for the determination of mebendazole in pure, pharmaceutical formulations and in camel urine.

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