ADENOVIRUS TYPE 5 REACTIVATION IN T- LYMPHOBLAST HUMAN CELL AFTER ETOPOSIDE TREATMENT
2020
Zeenah Weheed Atwan
Adenoviruses cause different types of human infections including, respiratory,conjunctivitis and gastrointestinal tract infection. Despite it causes infections in bothimmunocompetent and immunocompromised patients, it represents a real threat forthe latter group which makes it necessary to detect the infection, reasons underlyingreactivation and hence the appropriate treatment. The antineoplastic therapies such asetoposide could be a compromising agent that facilitates the spread of opportunisticinfections such as adenovirus. The study aimed to assess adenovirus copy number/cellbefore and after etoposide treatment. The results showed that the etoposide treatmentupregulated the replication of the virus to more than 2 fold as compared to theuntreated samples. The results revealed that the etoposide has the ability to reactivatethe virus when it starts to be latent.
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