Types of chromosomal abnormalities caused by chemotherapy cyclophosphamide in mice (Mus musculus L.)

Wasan Moayad Shaker; Zainab Abdul Rahman Mohammed Al tuma

Types of chromosomal abnormalities caused by chemotherapy cyclophosphamide in mice (Mus musculus L.)

1970

Wasan Moayad Shaker | Zainab Abdul Rahman Mohammed Al tuma

The current study was designed to study the genetic effects of Mus musculus L. on male and female laboratory mice. The study included the following: Cyclophosphamide's effects on chromosomal changes in bone marrow cells and testes, as well as a study of Cyclophosphamide's effects on the mitotic index of bone marrow cells and germ cells (testes). Cyclophosphamide dosing resulted in a (0.006mg/kg body weight) for 30 days . Chromosomal changes appear in bone marrow cells (chromatid gap, chromatid break, centromere gap, ring chromosomes, centromere break, deletion) within a statistically significant difference (0.004). Cyclophosphamide also led to the occurrence of chromosomal changes in testicular cells (chromatid gap, centromere break, centromere gap, ring chromosomes, polyploidy) at a statistically significant difference (0.046). The results of the study also showed that the activity of cyclophosphamide caused a significant decrease in the mitotic index of bone marrow cells at the duration of the dose . at a statistically significant difference (0.016). For calculating the mitotic factor of the germ cell (testes), the results showed a decrease in the dose while there were no significant differences (p≥0.05).

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