Preservative Sodium Benzoate as a Food Additive Alone and in Combination with Vitamin C and its Toxic Effects on the Liver and Kidney Function of Adult Male Rabbits
2022
Shahid Jalil | Nawras Alwan | Eman Al-Masoudi
The present study was designed to determine the adverse effect of sodium benzoate (SB), vitamin C (Vit.C) alone and their combination on liver and kidney functions in rabbits. Thirty-six adult male rabbits were divided randomly into six equal groups. Group 1 (Control group) received orally distal water, group 2: Vit.C (200mg/kg BW/day) received orally, group 3: received orally SB (60 mg/kg BW/day), group 4: received orally SB (120 mg/kg BW/day). Group 5: received orally SB+Vit.C (60+200 mg/ kg BW/day) and group 6: received orally SB+Vit.C (120+200 mg/ kg BW/day). The result revealed a significant increment in ALT, AST, ALP and MDA in groups 4, 5 and 6 while total protein levels increased in G3 and G4 and decrease in G5 and G6 compared to control and another treated groups. The urea and creatinine levels increased in G5 and G6 as compared to another groups. In conclusion that SB administration alone and together with Vit.C caused adverse effect on liver and kidney functions compared to the group treated with the Vit.C alone and control groups.
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