Evaluation of the Hepatotoxicity Induced by Captopril and Enalapril in Rat Liver: A Comparative Study
2023
Mohammed Ibrahim | Waseem Hassan Hassan | Mohammed Saeed
The aim of this study was to look into the toxicity of captopril and enalapril in high doses in the liver. The animals in this experiment were divided into five groups of ten each, with the first group serving as a control group, receiving only distilled water, the second and thrird groups receiving doses of captopril 10 and 20%, and the fourth and fifth groups receiving doses of enalapril 10 and 20%. The dose is taken orally once every three days for four weeks. After one week, samples were collected, and then again four weeks later. After one week of treatment with Enalapril 20%, biochemical testing revealed significant elevations in ALT and AST. After 1 and 4 weeks of treatment with Enalapril 20%, there was a decrease in glutathione and an increase in malondialdehyde, whereas captopril 20% and Enalapril 10 and 20% significantly raised malondialdehyde levels. Rats given captopril 20% revealed diffuse vacuolar degeneration. The 10% Enalapril group experienced similar symptoms, however the 20% Enalapril group experienced vacuolar degeneration, coagulative necrosis, significant inflammatory cell infiltration, portal vein congestion, and sinusoidal dilatation. The researchers looked at the expression of TNF-a in the livers of rats after four weeks of therapy with Captopril 10% and 20% and Enalapril 20% (20%). The results revealed three levels of expression: low, medium, and high. According to the findings of this study, Enalapril has higher adverse impacts on the liver than captopril at the same dose ratio.
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