Investigate the potential lung-protective effects of Hidrosmin and/or Vitamin C in rats with Bleomycin-induced lung fibrosis
2024
mohammad makki | Waleed Khalid Ghanim | Muhsin S. G. Al Mozie'l
As a chemotherapeutic agent, bleomycin is a glycopeptide antibiotic that is used to treat cancer. However, it is linked lung toxicity. Hidrosmin is a man-made flavonoid that reduces inflammation and protects cells from damage. Vitamin C is a water-soluble vitamin with the potential to reduce lung fibrosis. The experiment randomly assigned forty mature male rats into five groups. Group 1: control group with DMSO (5 ml/kg) for 20 days; Group 2: bleomycin intratracheally (5 mg /kg) on day seven of the experiment, Group 3; hidrosmin orally (300 mg/kg/day) for 20 days + BLE intratracheally (5 mg/kg) on day seven; Group 4: vitamin C orally (100 mg/kg/day) for 20 days + BLE intratracheally (5 mg/kg) on day seven; Group 5: hidrosmin orally (300 mg/kg/day) + vitamin C orally (100 mg/kg/day) daily for 20 days; and BLE (5 mg/kg) on day seven. The experiment randomly assigned forty mature male rats into five groups. The first group got DMSO (5 ml/kg) every day as a control. The second group got bleomycin intratracheally (5 mg/kg) on the seventh day of the experiment. The third group got hidrosmin orally (300 mg/kg/day) for 20 days and BLE intratracheally (5 mg/kg) on the seventh day. The fourth group got vitamin C orally (100 mg/kg/day) for 20 days and BLE intratracheally (5 mg/kg) on day seven. The fifth group got hidrosmin orally (300 mg/kg/day) plus vitamin C orally (100 mg/kg/day) every day for 20 days and BLE intratracheally (5 mg/kg) on the seventh day.
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