2024 taxonomy update for the family Circoviridae
Varsani, Arvind | Harrach, Balázs | Roumagnac, Philippe | Benkő, Mária | Breitbart, Mya | Delwart, Eric | Franzo, Giovanni | Kazlauskas, Darius | Rosario, Karyna | Segalés, Joaquim | Dunay, Emily | Rukundo, Joshua | Goldberg, Tony L. | Fehér, Enikő | Kaszab, Eszter | Bányai, Krisztián | Krupovic, Mart | Producció Animal | Sanitat Animal
Circovirids have a circular single-stranded DNA genome packed into a small icosahedral capsid. They are classifed within two genera, Circovirus and Cyclovirus, in the family Circoviridae (phylum Cressdnaviricota, class Arfviricetes, order Cirlivirales). Over the last fve years, a number of new circovirids have been identifed, and, as a result, 54 new species have been created for their classifcation based on the previously established species demarcation criterion, namely, that viruses classifed into diferent species share less than 80% genome-wide pairwise sequence identity. Of note, one of the newly created species includes a circovirus that was identifed in human hepatocytes and suspected of causing liver damage. Furthermore, to comply with binomial species nomenclature, all new and previously recognized species have been (re)named in binomial format with a freeform epithet. Here, we provide a summary of the properties of circovirid genomes and their classifcation as of June 2024 (65 species in the genus Circovirus and 90 species in the genus Cyclovirus). Finally, we provide reference datasets of the nucleotide and amino acid sequences representing each of the ofcially recognized circovirid species to facilitate further classifcation of newly discovered members of the Circoviridae.
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