The influence of milk thistle, metiphene, and sylimevit on the protein synthesis function of the liver of laying hens under cadmium load

Cadmium compounds deserve special attention from researchers, as this element belongs to the first class of environmental hazards. Cadmium is classified as a dangerous pollutant in the environment because it, due to toxic stress, causes various disorders of the functional state of the organisms of animals and birds. The work aimed to study the effect of milk thistle, metiphene, and sylimevit on the protein synthesizing function of the liver of laying hens under experimental chronic cadmium toxicosis. 32 laying hens aged 78 weeks were selected for the research. Four experimental groups were formed: a control group and three experimental groups. Chickens of the control group (K) and three experimental groups were given cadmium sulfate with water at 4 mg/kg of body weight. The chickens of experimental group D1 were fed milk thistle fruits at a dose of 2.0 g/kg of feed once a day for 30 days. Chickens of experimental group D2 were fed metiphene at a dose of 0.28 g/kg of feed once daily for 30 days. The chickens of experimental group D3 were fed sylimevit at a dose of 0.36 g/kg of feed once daily for 30 days. The research results showed that the content of total protein and its fractions in the blood plasma of laying hens changes throughout the experiment in birds of the control and experimental groups. Thus, in the blood of laying hens subjected to cadmium loading, a decrease in total protein and albumin fraction was found in their blood. Under the cadmium load of laying hens, milk thistle, metiphene, and sylimevit have a positive effect on the protein synthesis function of the liver, as indicated by an increase in the level of total protein and albumins. Analyzing the indicators of the content of total protein and protein fractions in the blood plasma of laying hens under cadmium load and the use of experimental drugs, it is worth noting that a probable difference between the birds of the control and experimental groups was observed from the 14th day of the experiment. Feeding with the fodder of the spotted thistle and silimevit contributed to a better normalizing effect on the protein synthesis function of the liver than the use of metiphene.