Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)
Hee Yang | Min Jeong Kang | Gihyun Hur | Tae Kyung Lee | In Sil Park | Sang Gwon Seo | Jae Gak Yu | Yong Sang Song | Jung Han Yoon Park | Ki Won Lee
Adipocyte differentiation (adipogenesis) is a crucial process that determines the total number and size of mature adipocytes that will develop. In this study, the anti-adipogenic effect of sulforaphene (SFEN), a dietary isothiocyanate (ITC) derived from radish, is investigated both in 3T3-L1 pre-adipocytes and in human adipose tissue-derived stem cells. The results revealed that SFEN significantly inhibit adipogenic cocktail-induced adipocyte differentiation and lipid accumulation at the early stage of adipogenesis. Additionally, the effects are more potent compared to those of other ITCs derived from various cruciferous vegetables. As a related molecular mechanism of action, SFEN promotes the post-translational degradation of CCAAT/enhancer-binding protein (C/EBP) &beta: by decreasing the stability of C/EBP&beta:, which is responsible for decreasing the expression of master regulatory proteins such as peroxisome proliferator-activated receptor &gamma: and C/EBP&alpha:. Collectively, these results suggest that the intake of SFEN-enriched natural materials could be helpful as a strategy for preventing obesity.
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