Combination of Standard Addition and Isotope Dilution Mass Spectrometry for the Accurate Determination of Melamine and Cyanuric Acid in Infant Formula
2024
Vasilisa Pedan | Rudolf Koehling | Lukas Drexel | Kathrin Breitruck | Alexander Rueck | Sascha Rohn | Olaf Rienitz | Axel Pramann | Tim Seidel | Eric Allenspach | Markus Obkircher
In the melamine scandals of the early 2000s, different companies of the dairy industry cheated their products by applying chemical substances to feign a higher content of nitrogen. However, this had a severe toxic impact on the kidney health of consumers. As a result, tremendous effort was put into the prevention of further harm to the public. In the present study, a fast&ndash:screening method for the determination of melamine and cyanuric acid in infant formula was developed. While a 1D&ndash:LC approach is faster and easier to set up, a 2D&ndash:LC approach allows for a more accurate result with better selectivity and sensitivity. For both instrumental approaches, the signal ratio of the isotopologues was crucial and had a dominant effect on the results and the measurement uncertainty. For this reason, the different contributions to the measurement uncertainty were determined experimentally using Matched Standard Addition&ndash:IDMS and compared to the Exact Matching Double IDMS.
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