Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the “Mamma & Bambino” Cohort and A Meta-Analysis
2018
Martina Barchitta | Andrea Maugeri | Maria Clara La Rosa | Roberta Magnano San Lio | Giuliana Favara | Marco Panella | Antonio Cianci | Antonella Agodi
The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes&mdash:including preterm birth (PTB), low birth weight and small for gestational age&mdash:is currently under debate. We investigated 187 mother-child pairs from the Italian &ldquo:Mamma &: Bambino&rdquo: cohort to evaluate the association of maternal VDR polymorphisms&mdash:BsmI, ApaI, FokI and TaqI&mdash:with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele (p = 0.040 and p = 0.010, respectively). Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049: 95% CI = 2.606&ndash:55.709: p = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18&ndash:11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74: 95%CI 0.59&ndash:0.93) and recessive (AA vs. GG + AG: OR = 0.62: 95%CI 0.43&ndash:0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of PTB.
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