Short-Term Associations of Traffic-Related Air Pollution with Cardiorespiratory Outcomes Among Low-Income Residents from a US–Mexico Border Community

Exposure to traffic-related air pollution is not merely linked to respiratory health issues but also poses significant risks to cardiovascular well-being. Individuals from lower-income communities residing in high-pollution zones are particularly vulnerable to adverse cardiorespiratory health impacts. Pollutants such as fine particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), and ozone (O3) are recognized as a leading, yet preventable, contributor to cardiorespiratory diseases. Although research has extensively explored the short-term impact of these pollutants on respiratory health, the immediate effects on cardiovascular outcomes require further study. We explored associations of traffic-related air pollutants with airway inflammation, lung function, and cardiovascular health outcomes (metabolic syndrome [MetS]) collected from a sample of low-income participants (N = 662) from a US&ndash:Mexico border county. Airway inflammation was measured using exhaled nitric oxide tests (eNO), while lung function parameters were measured by spirometry. MetS risk factors (waist circumference, blood pressure, triglycerides, HDL, and fasting blood glucose) were also measured. While spirometry measures were negatively associated with air pollutants (p &lt: 0.05), no associations were noted for eNO. We also found positive associations in linear and logistic models between air pollutants and obesity (BMI: p &lt: 0.04: waist: p &lt: 0.03), fasting blood glucose (p &lt: 0.03), and metabolic syndrome (p &lt: 0.04). These findings reaffirm the immediate adverse effects of air pollution on respiratory function and shed light on its broader metabolic consequences. Environmental and neighborhood conditions could potentially influence the associations with obesity. At the same time, the links between fasting glucose and metabolic syndrome might indicate underlying oxidative stress and systemic inflammation.