Research Progress on Types, Extraction and Biological Activity of Chlorogenic Acid Compounds
2025
Shuqi ZHAO | Yushuo ZHANG | Lifei WU | Zehao CHEN | Yu CAO | Liangfu ZHOU | Wen ZHAO | Qian ZHOU
Chlorogenic acid compounds, a type of natural phenolic acid compounds, are mainly found in natural plants such as Eucommiae Cortex and honeysuckle. At present, the studies on chlorogenic acid compounds are mainly focused on the determination of content, the optimization of extraction method，the evaluation of biological activities and the related mechanism. More than 20 kinds of plants species was detected for the different types of CGAs, and the extraction methods mainly focused on the water extraction, organic solvent extraction, enzymatic extraction, ultrasonic and microwave assisted extraction, and novel extraction methods based on critical technology. The studies about functional activity showed that chlorogenic acid compounds had various biological activities such as antioxidant, anti-inflammatory, regulation of immunity, regulation of blood glucose and lipid, antibacterial, and anti-tumor effects, and could be applied in the fields such as food antioxidant and antibacterial. Based on these findings, this article summarizes and prospects, to provide a theoretical basis for the fields of health food, functional food, and pharmaceuticals, for further optimizing the extraction and preparation methods suitable for the industrial production, clarifying the mechanisms of biological activities, and identifying their application values as antioxidant, antibacterial and preservatives.
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