Phytochemical Composition and Antioxidant Activity of a <i>Viscum album</i> Mother Tincture
Paola Imbimbo | Carolina Fontanarosa | Angela Amoresano | Daria Maria Monti | Gennaro Battaglia | Marcello Nicoletti | Michele Spinelli | Gerhard Schaller | Vincenzo Rocco
In the last decades, extracts of <i>Viscum album</i> L., commonly known as European mistletoe, have attracted increasing interest for their immunomodulatory, anti-inflammatory and antioxidant activities. Nowadays, they are mainly used in complementary cancer treatments. A targeted LC-MRM-MS was selected to determine the chemical composition and the activities of a <i>V. album</i> homeopathic mother tincture (MT#39998). Results showed a complex chemical composition, which was compared with that of other similar extracts. The LC-MRM-MS data were confirmed and complemented by HPLC analysis. Viscotoxins content was evaluated because of their cytotoxicity. MT#39998 was tested for its cytotoxic and antioxidant effect, before and after viscotoxins removal. The composition of MT#39998 in viscotoxins was similar to that of other products already present in the market and its safety was confirmed by estimation of LD<sub>50</sub> based on in vitro IC<sub>50</sub> values (LD<sub>50</sub> was >2 g/kg). The aim of this study is to report a case study on a plant extract. The study was based on the chemical composition, including the metabolome, and on the pharmacological data, including toxicity and antioxidant activities, to validate the current utilization.
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