Toxicological evaluation of an iron-containing veterinary drug and environmental aspects of its residue disposal
2025
Sachuk, R. M. | Velesyk, T. A. | Gutyj, B. V. | Kolinko, I. Yu. | Vyhovskyi, I. V. | Kalabska, O. | Katsaraba, O. A.
The article highlights the results of a comprehensive study of toxicological safety and environmental risks associated with using the iron-containing veterinary drug “Ferodev” (solution for injection), which contains the active substance - iron in the form of hydroxide-dextran complex. The purpose of the study was to determine the parameters of acute toxicity of the drug under the conditions of its intragastric administration to laboratory animals (male white rats) and to analyze the possible consequences of the drug residues entering the environment. During the experiment, it was established that the drug belongs to class V in terms of toxicity – practically non-toxic substances, and to class IV in terms of the degree of danger. At the same time, considering the potential cumulative effect of iron and auxiliary components of the drug, particularly phenol, indicates environmental risks in improper disposal. The need to comply with regulated methods of handling drug residues that ensure environmental safety and reduce the threat to soil and aquatic ecosystems is substantiated. Special attention was paid to the analysis of pathoanatomical changes in animals depending on the level of the administered dose of the drug. Changes in behavior, functional state of internal organs, and mortality depending on the toxicological load were noted. The results of the study indicate the presence of a dose-dependent reaction of the body, which may be important for determining the safe range of use of the drug. An assessment of current approaches to environmentally safe disposal of pharmacological residues was carried out. The data obtained can be used for further regulatory developments in veterinary medicine and environmental protection. Further research will focus on developing regulated methods for environmentally safe disposal of iron-containing veterinary drugs and studying their cumulative impact on biocenoses.
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