Effectiveness of medicines for Trichurosis of the nutritae

The launch of new drugs against productive and small animal parasites is due to informed consumers' requirements. It aims to expand the existing range of effective drugs that provide long-term action, acting against both ecto- and endoparasites, taking into account a convenient method of administration. For trichuriasis of farm animals, drugs based on different active ingredients are used. Data on the effectiveness of medications for parasitosis of nutria (Myocastor coypus Molina, 1782) are absent in Ukraine, although the circulation of Trichuris myocastoris (Enigk, 1933) has been proven. That is why our work aimed to determine the effectiveness of domestic anthelmintics for the localization of trichuriasis in the intestine of the nutria. Accordingly, for the experiment to determine the therapeutic efficacy indicators, three experimental groups of semi-aquatic rodents with an average intensity of trichuriasis invasion (from 304.9 ± 13.7 to 316.9 eggs/gram) were formed. The therapeutic efficacy of Profiverm injection 1 %, Profiverm granulate (active ingredient for both preparations – ivermectin), and Levamisole 8 % (levomisole hydrochloride), PE “O.L.KAR-AgroZooVet-Service”, Ukraine, was tested. It was found that their efficacy depended on the method of administration and the chemical group to which they belonged. It was proven that macrocyclic lactones have the highest nematocidal properties against the causative agent of nutria trichuris, both in the case of subcutaneous administration and in the form of a therapeutic-feed mixture. In the case of spontaneous invasion, it was found that on the seventh day after deworming, the efficacy of Profiverm injection was 1 % and 81.8 %, and the efficacy of Profiverm granulate was 90.9 %. On the 14th and 21st day after deworming of nutria, the effectiveness of the drugs was 90.9 % and 100.0%, respectively. Less effective at the end of the experiment (EE 63.6 % for IE of 85.0 %) was the use of Levamisole 8 %. Field tests showed that the veterinary drug Profiverm granulate, when applied three times to the therapeutic feed mixture in the manufacturer's recommended doses, was well tolerated by spontaneously affected nutria 6 months of age and did not have a toxic effect on the invaded organism.