Design and Evaluation of Liposomal Formulation of Carob (ceratonia Siliqua L.) Pulp Extract
2024
Dekanski, D. | Rašković, A. | Martić, N. | Pirković, A. | Jovanović, A.
The carob (Cerationa siliqua L.) pulp flour is used primarily in the food industry. As a valuable source of bioactive compounds (polyphenols), it is a good candidate for pharmaceutical formulation research and development. In this study, carob pulp extract-loaded liposomal particles were developed using the proliposome procedure and characterized via encapsulation efficiency (EE), vesicle size, polydispersity index (PDI), zeta potential, mobility, and viscosity. The obtained results suggest that the EE is high (80.6±3.3%). The particle size and PDI results indicated the existence of the multilamellar and uniform liposomal system. Lower values of zeta potential and mobility (-17.8±1.0 mV and -1.40±0.08 µmcm/Vs, respectively) of developed liposomes suggest that future experiments should be focused on the carob pulp liposomal nutraceutical formulation improvement, particularly its stability.
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Издатель Vinča Institute of Nuclear Sciences – National Institute of the Republic of Serbia, University of Belgrade
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