Early host-parasite interaction models reveal a key role for fibrinolysis in Fasciola hepatica intestinal migration
2025
Serrat, Judit | López García, Marta | Torres Valle, María | Molina Hernández, Verónica | Ruiz Campillo, M. Teresa | Siles Lucas, Mar | González Miguel, Javier | Ministerio de Ciencia, Innovación y Universidades (España) | Agencia Estatal de Investigación (España) | European Commission | Junta de Castilla y León | Serrat, Judit [0000-0002-1182-1088] | López García, Marta [0000-0002-7412-4597] | Torres Valle, María [0000-0003-0503-2688] | Siles Lucas, Mar [0000-0002-1257-2562] | González Miguel, Javier [0000-0003-4279-4761] | Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
17 páginas, 4 figuras y una tabla
Показать больше [+] Меньше [-]Fasciola hepatica is the most common etiologic agent of fasciolosis, a parasitic disease that affects millions of ruminants worldwide and a zoonotic human infection of public health concern. Upon ingestion of infective metacercariae, F. hepatica newly excysted juveniles (FhNEJ) emerge in the duodenum and cross the intestinal wall to initiate a migration route that culminates with their establishment within the hepatic bile ducts. The ability of FhNEJ to exploit the broad-spectrum activities of host plasmin, the central protease of the fibrinolytic system, has been proposed as a strategy employed by these parasites to migrate across the intestinal wall while minimising energy expenditure.
Показать больше [+] Меньше [-]J.G.M. acknowledges funding received from projects ULYSSES (RTI2018-093463-J-100) and PERSEUS (PID2023-152150OB-C21) funded by MICIU/AEI/https://doi.org/10.13039/501100011033 and FEDER, EU, and URANUS (CNS2022-135561) funded by MICIU/AEI/https://doi.org/10.13039/501100011033 and NextGenerationEU/PRTR. J.S. acknowledges the support of the Junta de Castilla y León for her predoctoral contract. M.L.G. acknowledges the support of the Spanish Ministry of Science and Innovation for her FPU predoctoral contract.
Показать больше [+] Меньше [-]Peer reviewed
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