Objective: The objective of this study was to evaluate the benefits of the clinical outcome of meniscal injury diagnosis and surgical management during the reconstruction of cranial cruciate ligament rupture (RCCL) in dogs. Materials and methods: For these purpose two groups with 2 different surgery regimens; group 1 (G1), RCCL was corrected with partial meniscectomy and tibial tuberosity advancement (TTA), and another one (group-2, G2) only with TTA. Long-term follow-up about postoperative complications and any recurrence of signs were recorded by referring veterinarians by medical questionnaire over telephone contact and radiographic postoperative follow-up of bone healing was evaluated. Results: Meniscal injuries were diagnosed arthroscopically in five dogs out of six dogs, and corrected by partial meniscectomy arthroscopically. The percentage of presence of meniscal injury was 83%. It was found that clinical outcomes were superior in G1 than G2 group both walking starting time (4.6&plusmn;2.5 and 6.4&plusmn;2.9 days, respectively) or full recovery time (39.2&plusmn;26.9 and 58.1&plusmn;24.5 days, respectively) was significantly shortage (P<0.05) along with less postoperative complication at two years postoperative observation. Out of the five dogs, lameness, arthritis was developed in four dogs in G2 group while the number of dogs was two in G1 group within two years. Conclusion: Finally based on the clinical superiority, it is recommended that meniscal injury should be checked and corrected during RCCL reconstruction for getting better clinical outcomes. [J Adv Vet Anim Res 2017; 4(3.000): 311-318]

Objective: This study was carried out to investigate the effects of estradiol benzoate (EB) injection to male rabbits on glucose, total-protein, albumin, calcium concentrations and prostate tissue, and the role of prolactin as an important mediator of estrogen action in prostate. Materials and methods: Fifty four adult male rabbits were used in this study. The rabbits were randomly divided into two groups. Group A contained 36 male rabbits, which were further randomly divided into four sub-groups, three of them contained 10 rabbits and one sub-group contained 6 rabbits as control. Group B contained 18 male rabbits, which were divided randomly into three equal sub-groups. Three sub-groups of Groups A and B were treated once each on alternative day with the intramuscular injections of EB dosed at 40, 80 and 120 &micro;g/rabbit, respectively for 20 days, whereas the fourth sub-group of Group A received no estradiol, and Group B received 1 mg Bromocriptine Mesilate in addition to EB through oral route on each alternative day. Blood samples were collected for measuring glucose, t-protein, albumin and calcium levels. Prostate tissue samples were collected from all the rabbits for histological studies. Results: Glucose was significantly (P&#706;0.05) increased as a result of 80 &micro;g EB injection, while significantly (P&#706;0.05) decreased due to 40 and 120 &micro;g EB injection. Total protein significantly (P&#706;0.05) increased due to injection of 40 &micro;g EB, however t-protein was not changed due to 40 and 120 &micro;g injection. On the other hand, the results of albumin and calcium were not affected (P&#707;0.05) by EB. In prostate tissues, EB induced hyperplasia with dysplasia or dysplasia only, but this effect was mild due to inhibition of prolactin. Conclusion: The injection of EB to male rabbits increased or decreased glucose level, increased t-protein level mildly or not changed, while albumin and calcium levels were not affected. EB induced hyperplasia on prostate tissue, and this effect was reduced by prolactin inhibition indicating that prolactin might have a role on the action of estrogen. [J Adv Vet Anim Res 2017; 4(1.000): 15-21]