Plasma and tissue levels of trimethoprim in the rainbow trout, Salmo gairdneri, after absorption from fresh and salt water [salmon]
1980
Bergsjoe, T. | Soegen, E. (Norges Veterinaerhoegskole, Oslo. Dept. of Pharmacology and Toxicology)
This is a comparative study of uptake of trimethoprim from 1: fresh water, 2: salt water after 7 days of adaptation and 3: salt water without previous adaptation. The rate and extent of absorption were found to vary significantly. The salt water adapted group reached a plasma concentration of approx. 1 mu-g: ml after 10 h, the unadapted salt water group after 24 to 48 h and the fresh water group did not reach this concentration. The results are discussed in relation to the non-ionic diffusion theory and to the alterations taking place in euryhaline species of fish during adaptation to salt water.
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