[Organic levels of PTU [propylthiouracil] in treated steers and its effect on arterial pressure]
1986
Recio, P. | Cruz, L.F. de la | Illera, M. (Universidad Complutense de Madrid (Spain). Dept. de Fisiologia Animal)
We have determined the thiouracil levels in plasma, thyroid, muscle and liver. On the other hand, we have obtained the value of water content in tissues of treated steers with 5-propylthiouracil (dose 5g/day). In the same way we have studied the effect in laboratory animals (cats) on arterial pressure using the similar doses to those we detected in treated steers. We can observe significative values of PTU at different organic levels. These values we detected in treated steers. Arterial pressure is clearly diminished with this drug. The effect of hypotension is correlated with the binomial dose response
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