Effects of diltiazem on norepinephrine-, phenylephrine- and clonidine-induced pressor response in rabbits
1988
Shin, D.H. (Chonnam National Univ., Kwangju (Korea R.). Coll. of Veterinary) | Choi, S.H. (Chonnam National Univ., Kwangju (Korea R.). Coll. of Pharmacy)
To examine the selectivity of diltiazem, used in the cardiovascular diseases, on alpha-1 and alpha-2 adrenoceptor-induced pressor responses, effect of diltiazem on alpha-adrenoceptor agonist-induced pressor responses were investigated in urethane-anesthetized rabbits and spinal rabbits. Intravenous diltiazem(10,30,100,300,1000 micro g/kg) produced dose-dependent depressor response in rabbits. Pressor responses to intravenous norepinephrine(10 micro g/kg) and phenylephrine (30 micro g/kg) were inhibited by pretreatment with intravenous diltiazem in rabbits and no difference was noted between the degree of both inhibitions of the pressor response by diltiazem. Pressor responses to intravenous norepinephrine (3 micro g/kg), phenylephrine (20 micro g/kg) and clonidine (300 micro g/kg) were inhibited by pretreatment with intravenous diltiazem in spinal rabbits. No difference was noted between the inhibition of norepinephrine-induced pressor response and that of phenylephrine-induced pressor response by diltiazem. The inhibition of clonidine-induced pressor response by diltiazem was slightly more prominent than that of norepinephrine-or phenylephrine-induced pressor response. These results suggest that diltiazem significantly inhibits both pressor responses mediated by alpha-1 and alpha-2 adrenoceptors
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