Embryotoxic effect of Lupinus termis seeds in rats
1984
Hashim, M.M. | Pettigrew, A.B. (King Abdulaziz Univ., Jeddah (Saudi Arabia). king Fahd Medical Research Centre)
The present work was conducted to study the embryotoxic effects of Lupinus termis seed extract. Examination of both uterine horns on the 20th day of gestation, after administration of the extract in doses of 50 and 100 9/100 g b.wt. revealed foetal resorption of 50% and 65.93% respectively. Foetal weight and foetal length were both reduced to 25.3 + 0.70 mm and 23.65 + 0.08 mm, and 3.77 + 0.10 g and 2.92 + 0.15 g respectively, compared to the control group. Skeletal examination showed the following malformations: Skull, 10% and 13.3% Vertebral column, 16.6% and 8.3%; Ribs, 13.3% and 25%; Sternebrae, 8.3% and 10%; Limbs, 53.3% and 66.6% respectively. Results of the visceral examination were: Brain malformation, 10% and 12.5%; Palate, 7.5% and 15%; Heart, 12.5% and 22.5%; Lung, 0% and 0%: Liver, 31.25% and 37.5%; kidney, 27.5%, and 27.5%, respectively.
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