Inhibtion of Gluconeogenesis in rat by L-tryptophan and its metabolites [Egypt]
1986
Ismail, S.A. (Cairo Univ., Fayoum (Egypt). Faculty of Agriculture) | Sharada, H.M. | Mohamed, Z.A. | Abdalla, M.S.
These studies were designed to define whether the effect of trypotophan on gluconeogenesis in rats was due to the amino acid itself or to one of its metabolites. Several tryptophan metabolites in different pathways were used in the present study. Quinolinate and 3 -hydroxyanthranilate were chosen from tryptophan -nicotinic acid pathway and tryptophan degradative products. The effect of 5- hydroxytryptamine and its precursor, 5- hydroxytryptophan were also studied. Tryptamine and indol - 3- acetate were also used in this study, as indolic derivatives. The effects of 3- hydroxyanthranilate and quinolinate on the blood glucose level, hepatic content of glycolytic and gluconeogenic intermediates and the activity of hepatic phosphoenolpyruvate carboxykinase were similar to those obtained by tryptophan administration. It may be concluded that the effect of tryptophan on gluconeogenesis may be due to accumulation of quinolinate in liver of rat.
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