Antiviral effect of tiazofurin to barley stripe mosaic virus
1988
Nagy, P.D. | Gaborjanyi, R. (Magyar Tudomanyos Akademia, Budapest (Hungary). Novenyvedelmi Kutato Intezet) | Kovacs, L. | Farkas, I. (Kossuth Lajos Tudomanyegyetem, Debrecen (Hungary). Szerves Kemiai Intezet)
Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) was found to inhibit barley stripe mosaic virus (BSMV) in barley and wheat plants. Treatments with this nucleoside analogue caused delay and inhibition of symptom development, and suppression of virus multiplication. The most efficient concentration to reduce the virus content, without significant phytotoxicity, was 0.001 M applied as a foliar spray three hours and one day after inoculation. Tiazofurin was more effective against the "Braunschweig" strain (BSMV - Br) which caused severe mosaic symptoms and tissue necroses, then against the mild, Hungarian strain (BSMV - H). Wheats were shown to have less sensitivity to this drug than barley plants. Three weeks after treatment the antiviral effectivity declined.
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