Physiological characteristics of histamine receptor of the isolated renal artery in dog
1989
Kim, J.H. | Nam, Y.J. (Kyongsang National Univ., Chinju (Korea R.). Coll. of Veterinary Medicine)
To elucidate the physiological characteristics of histamine receptor of the isolated renal artery in dog, effects of various receptor blockers and Ca++ channel blockers on the contractile responses of histamine were investigated in the isolated renal artery of dog. Histamine caused the contraction in the isolated renal artery of dog, and the contractile responses increased between the concentration of 5 x 10** (-6)M and 10** (-2)M in dose-dependent manner. The contractile response induced by histamine (10** (-3)M) was not blocked by pretreatment with atropine (10** (-6)M), phentolamine (10** (-6)M), propranolol (10** (-6)M) or cimetidine (10** (-6)M), but was completely blocked by pretreatment with pyrilamine (10** (-6)M). The contractility induced by histamine (10** (-3)M) was decreased in the Ca++ free medium. The contractile response induced by histamine (10** (-3)M) was decreased in the Ca++ free medium. The contractility induced by histamine (10** (-3)M) was markedly inhibited by pretreatment with papaverine (5x10** (-5)M) or verapamil (5x10** (-5)M). After the pre-contraction induced by norepinephrine (10** (-7)M) or prostaglandin F2 alpha (5x10** (-6)M), the contractile response induced by the additional treatment of histamine (10** (-3)M) was markedly increased compared with that of histamine (10** (-3)M) alone
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