Vaccines for duck cholera and duck plaque III. Immunity of combined vaccines: Formalinized bacterin plus attenuated duck plaque vaccine
1985
Sattaporn Srimahasongcram | Areerat Pongsopida | Pakorn Tweeshotipat (Chulalongkorn Univ., Bangkok (Thailand). Faculty of Pharmaceutical Science)
Comparative study on the immunity of the combined and single vaccines of duck cholera and duck plaque was performed. The duck cholera vaccines, one from the Department of Livestock (DCL) and another was prepared in out laboratory, (DCO) were used to combine with duck plaque (DP) vaccine from the Department of Livestock. Each kind of vaccines was vaccinated twice into ducks at 4 weeks intervals. The antibody titers to duck cholera and duck plaque were determined by Tube Agglutination Test and Neutralization Test respectively. The immunity of the vaccinated duck was conducted by challenging the animal with Pasteurella multocida and duck plaque virus at 7th and 8th week respectively after the first vaccination. The highest antibody titers to duck cholera was obtained one week after the first vaccination of either single or combined vaccines. However, the titer form the monovalent vaccinated animal was higher than the others. The antibody level against duck plaque was the highest in one week following the 2nd vaccination. The Neutralizing Index from single vaccine was higher than the combined vaccines, DCL plus DP but lower than the other, DCO plus DP. The immunity against duck cholera was 100 % protection in both single and combined vaccines, except the combined vaccine (DCO plus DP) produced 40 % protection. The immunity against duck plaque virus challenging was 100 % protection in either single or combined vaccines administrations.
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