Histopathological study on experimental ovine lymphosarcoma by bovine leukemia virus
1992
Ohtsu, Y. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) | Tsutsumi, M. | Okada, K. | Ohshima, K.
Bovine leukemia virus (BLV) is known as a causative factor of enzootic bovine leukemia (EBL). Sheep are susceptible to BLV and ovine lymphosarcoma (OLS) is produced within several years. Accordingly, sheep is considered to be an useful model for EBL. Eight sheep, Corridale and Suffolk bread aged 4 to 6 months old, were subcutaneously inoculated with BLV materials. Blood samples were collected periodically. Blood cell count, differential leukocyte count, and antibodies to BLV were examined. All sheep were observed grossly and histopathologically. BLV was detected from all sheep tested. All sheep developed leukemia and the white blood cell counts were 566,000/cmm in the highest at their terminal stages. Neoplastic lesions were observed grossly and diagnosed lymphosarcoma histopathologically. Sheep used for the present experiment were affected with lymphosarcoma within 2 to 4 years, and the histopathological lesions were nearly common to those of EBL. Accordingly, it was found that the sheep is a good model for EBL as well as for studies on BLV
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