Quantitative analysis of bovine lactoperoxidase system components and of the effects of the activated system on bacterial growth and survival
1994
Pruitt, K.M. (Alabama Univ., Birmingham (USA)) | Kamau, D.N.
During the last two decades the detailed chemistry of the bovine lactoperoxidase system has been determined. Although the lactoperoxidase enzyme is present at high concentrations in bovine milk, additional components are required to produce antibacterial effects. All of the components of the lactoperoxidase system, including the major products responsible for the antimicrobial effects, are now known. Accurate analytical methods are available for determining the concentrations of these components. The major chemical reactions responsible for the antimicrobial effects of the lactoperoxidase system have been identified. Mathematical models have been developed to describe these antimicrobial effects quantitatively. These models may be applied to experimental data by utilizing commercial software packages implemented on personal computers. In this report, we review the biochemistry of the lactoperoxidase system. We summarize the methods available for analysis of the system components, and we give examples of applications of mathematical models to bacterial growth and survival data.
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