Use of immunohistochemical techniques in the diagnosis of tumors in veterinary medicine
1993
Quezada O, Manuel (Concepcion Univ., Chillan (Chile). Fac. de Medicina Veterinaria) | Ruiz, Antonio | Carrasco, Librado | Gomez-Villamandos, Jose C. | Sierra, Miguel A. | Martin de las Mulas, Juana
The use of immunohistochemical (IHC) techniques in routinely processed tissue samples has greatly increased during the last decade, particularly in human oncology, due to both the higher capacity of newer IHC techniques to amplify lower antigenic signals and the development of monoclonal and polyclonal antibodies to several tumor-associated as well as the applications of these IHC techniques to tumor pathology in domestic animals. Several authors have confirmed the high cross-reactivity between human and animal proteins which serve as tumor markers, and also the feasibility of use of IHC techniques in Veterinary Pathology, as they allow the differentiation of tumors by cellular origin (intermediate filaments, synaptophysin) or cell type (endothelial, and histiocytic antigens, S-100 protein, carcinoembryonic antigen, alpha-fetoprotein). The present work represents a revision of those tumor tissue markers which have been shown to be most useful in diagnostic oncology
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