The effect of 6-hydroxydopamine on the arthus phenomenon and delayed skin hypersensitivity reactions to bovine serum albumin
1993
Cupic, V. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia). Department of Pharmacology) | Varagic, V.M. | Radulovic, J.
In order to produce chemical sympathectomy, Wistar rats were pretreated with 6-hydroxydopamine (6-OHDA), a substance known to produce general depletion of catecholamines from their stores. 6-hydroxydopamine was injected either intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) into animals immunized with bovine serum albumin. The results obtained indicate that pretreatment with 6-hydroxydopamine, both after single and repeated injections, decreased the Arthus phenomenon and delayed skin hypersensitivity reaction.
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