Differences in the N-acetylneuraminic acid content of serum, urine and feces between breast-fed and formula-fed infants
1995
Idota, T. (Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama (Japan). Technical Research Inst.) | Sugawara, M. | Nakajima, I. | Ueda, A.
The content of N-acetylneuraminic acid (NeuAc) in serum, urine and feces from breast-fed and formula-fed infants at 2-7 days after delivery was determined. The serum content of NeuAc in breast-fed infants was 41.2 +- 8.58 mg/dl and that in formula-fed infants was 37.0 +- 5.45 mg/dl, the later being significantly lower (p0.05). The ratio of NeuAc to creatinine in urine of breasted-fed infants was 0.390 +- 0.079 and that of formula-fed infants was 0.294 +-0.081 (p0.05). The content of NeuAc in feces of breast-fed infants was NeuAc excreted into urine and feces was 18.6 mg/day and 45.9 mg/day in breast-fed infants, and 14.0 mg/day and 23.6 mg/day in formula-fed infants. High performance thin-layer chromatography revealed little 6'-sialyllactose in urine and feces of formula-fed infants. These differences may be because human milk contains more NeuAc than infant formula
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