Effect of local anesthetic and beta-blocker carbisocaine on phospholipid polymorphism
1994
Balgavy, P. | Uhrikova, D. (Komenskeho Univ., Bratislava (Slovakia). Katedra Fyzikanej Chemie) | Ondrias, K.
Molecules of local anesthetic and beta/adrenoceptor blocker 2-(heptyloxy)phenyl-2-(diethylamino)-1-methylethylester of carbamic acid (carbisocaine) intercalate between phospholipids in total rat brain lipid (RBTL) bilayers at neutral pH values as cations and induce a change in the phospholipid head group orientation and conformation. In RBTL-H2O systems, carbisocaine reduces swelling and induces isotopic and hexagonal H sub(II) phases consisting of inverted tubules at 0.1:1 less than carbisocaine:RBTL less than 0.5:1 molar ratios and D20:RBTL=1:1 - 4:1 weight ratios. Non-bilayer RBTL phases convert to swelling bilayer phase at carbisocaine:RBTL = and bigger than 0.5:1 molar ratios. The observed polymorphism can be related to lipid metabolism in cells in the presence of local anesthetics and beta-blockers.
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