The influence of insulin on the activity of antioxidant enzymes in the rat interscapular brown adipose tissue and hypothalamus
1994
Radojicic, R. | Cvijic, G. | Djurasevic, S. | Davidovic, V. (Faculty of Biology, Belgrade (Yugoslavia). Institute of Physiology and Biochemistry)
Daily injection of both applied doses of insulin over a 7 day period, induced a dose -dependent decrease in the blood glucose concentration. However, despite severe hypoglycemia, insulin stimulated significantly the activity of both superoxide dismutase (CuZn SOD and Mn SOD) forms in the interscapular brown adipose tissue but had no effect on catalase activity. Moreover, insulin administration, irrespective of the dose applied, did not cause any change in the activity of any of the hypothalamic enzymes studied. These results suggest that the response of the main enzymes of antioxidant defence to chronic insulin treatment is tissue dependent. They also indicate that insulin probably regulates the activity of both superoxide dismutase forms in the interscapular brown adipose tissue only, but is ineffective in the hypothalamus.
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