Destabilizing effect of calcium on microtubules in vitro
1995
Gal, V. (Medical Faculty, Belgrade (Yugoslavia). Institute of Biophysics) | Danilovic, N. | Suzic, S.
The extent of disassembly of microtubules induced by calcium has been determined at various temperatures. The effect of calcium increases with decreasing temperature. Length distributions of microtubules were measured before and after partial disassembly under the influence of calcium and in steady in the presence of calcium. Partial disassembly due to calcium resulted in shorter microtubules indicating endwise disassembly. Calcium in steady state induced an increase of length implying that the influence of microtubule associated proteins (MAPs) is suppressed and that dynamic instability is pronounced.
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